Tolerance of the human spinal cord to high energy p(66)Be(49) neutrons
The risk of post irradiation myelopathy was evaluated in 76 patients followed for 1-5 years after neutron irradiation of the cervical and thoracic regions. No overt myelopathy was observed. Forty-six patients received doses (central cord dose) in excess of 10 Gy, 9 received doses in excess of 12 Gy, and 5 received doses between 13 and 17 Gy, all without any evidence of spinal cord injury. A review of available literature revealed a total of 14 patients with myelopathy, 13 of whom received doses in excess of 13 Gy delivered with relatively low energy neutrons generated by the deuteron + beryllium reaction. It is concluded from these studies that the tolerance limit for the human spinal cord irradiated with high energy (p(66)Be(49)) neutrons is close to 15 Gy, above which the risk of cord injury becomes significant. Central cord doses of 13 Gy or less appear to be well tolerated with little, if any, risk of myelopathy. These conclusions are valid for a treatment time of 4 weeks or more with two or more fractions per week (9 or more fractions). The RBE for the human spinal cord irradiated under the above conditions compared with conventionally fractionated photon therapy does not exceed 4.0.
- Research Organization:
- Fermilab Neutron Therapy Facility, Batavia, IL
- OSTI ID:
- 5436434
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 11:4
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
FAST NEUTRONS
RBE
NEUTRON THERAPY
SIDE EFFECTS
SPINAL CORD
DELAYED RADIATION EFFECTS
RADIOSENSITIVITY
PATIENTS
RADIATION DOSES
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
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ELEMENTARY PARTICLES
FERMIONS
HADRONS
MEDICINE
NERVOUS SYSTEM
NEUTRONS
NUCLEAR MEDICINE
NUCLEONS
RADIATION EFFECTS
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