Quantitative studies of human cardiac metabolism by /sup 31/P rotating-frame NMR
The authors have developed /sup 31/P NMR spectroscopic methods to determine quantitatively relative levels of phosphorus-containing metabolites in the human myocardium. They have used localization techniques based on the rotating-frame imaging experiment and carried out the double-surface coil probe. Information is obtained from selected slices by rotating-frame depth selection and from a complete one-dimensional spectroscopic image using phase-modulated rotating-frame imaging. The methods collect biochemical information from metabolites in human heart, and they use the fact that the phosphocreatine/ATP molar ratio in skeletal muscle at rest is higher than that in working heart to demonstrate that localization ha been achieved for each investigation. The phosphocreatine/ATP molar ratio in normal human heart has been measured as 1.55 +/- 0.20 in six subjects using dept selection and as 1.53 +/- 0.25 in four subjects using spectroscopic imaging. Measurement of this ratio is expected to give a useful and reproducible index of myocardial energetics in normal and pathological states.
- Research Organization:
- John Radcliffe Hospital, Oxford, England
- OSTI ID:
- 5435170
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 84:12
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HEART
DYNAMIC FUNCTION STUDIES
NUCLEAR MAGNETIC RESONANCE
METABOLISM
METABOLITES
MYOCARDIUM
PATIENTS
PHOSPHOCREATINE
PHOSPHORUS 31
AMINO ACIDS
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHORUS ISOTOPES
RESONANCE
STABLE ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics