Reaction of the hydroxyl radical with glutathione in neutrai and alkaline aqueous solution
Journal Article
·
· Radiat. Res.; (United States)
- Royal Inst. of Tech., Stockholm, Sweden
The reaction of OH with glutathione (..gamma..-glu-cys-gly) in neutral and alkaline aqueous solutions has been studied by pulse radiolysis. In addition to the sulfur-centered GS-(GSSG/sup -/.) radical formed by electron transfer or hydrogen abstraction from GS/sup -/ (GSH), at least one carbon-centered radical is formed with pH-dependent yield by hydrogen abstraction from the ..gamma..-glutamyl moiety. The latter radical is transformed in a first-ordered reaction most probably to a carbon-centered radical on the cysteine group. No evidence for the formation of carbon-centered radicals was found in comparable experiments with cysteine and 2-mercaptopropionylglycine.
- OSTI ID:
- 5431000
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 89:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560111* -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
CARBON
CARBOXYLIC ACIDS
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHEMISTRY
CYSTEINE
DECOMPOSITION
DRUGS
ELEMENTS
GLUTATHIONE
GLYCINE
HYDROGEN
HYDROXYL RADICALS
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXIDATION
PEPTIDES
PH VALUE
POLYPEPTIDES
PROTEINS
RADIATION CHEMISTRY
RADIATION EFFECTS
RADICALS
RADIOLYSIS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY
SULFUR COMPOUNDS
THIOLS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
CARBON
CARBOXYLIC ACIDS
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHEMISTRY
CYSTEINE
DECOMPOSITION
DRUGS
ELEMENTS
GLUTATHIONE
GLYCINE
HYDROGEN
HYDROXYL RADICALS
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXIDATION
PEPTIDES
PH VALUE
POLYPEPTIDES
PROTEINS
RADIATION CHEMISTRY
RADIATION EFFECTS
RADICALS
RADIOLYSIS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY
SULFUR COMPOUNDS
THIOLS