Effects of zinc and cholesterol/choleate on serum lipoproteins and the liver in rats

Journal Article · Sun Jan 01 04:00:00 EST 1989 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(89)90405-0· OSTI ID:5429431

Cho, C H; Chen, S M; Ogle, C W; Young, T K ^[1]

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1. Univ. of Hong Kong

The effects of short-term treatment with orally-administered zinc sulfate and/or a mixture of cholesterol/choleate on serum lipoprotein and hepatic enzyme levels were studied. Administration of graded doses of zinc sulfate for 5 days, dose-dependently increased serum and hepatic zinc levels but depressed the serum high-density lipoprotein-cholesterol (HDL-C) concentration and liver cytochrome P-450 activity. However, it did not affect hepatic concentrations of malondialdehyde and free {beta}-glucuronidase. Cholesterol/choleate treatment for 5 days markedly damaged the liver, as reflected by elevations of hepatic concentrations of malondialdehyde (both in the mitochondrial and microsomal fractions) and of free {beta}-glucuronidase; total cholesterol and low-density lipoprotein-cholesterol in the blood were increased, whereas HDL-C was decreased significantly. Concomitant administration of zinc sulfate with cholesterol/choleate further lowered HDL-C levels, but reversed the high hepatic concentrations of both malondialdehyde and free {beta}-glucuronidase. The present study indicates that both zinc ions and cholesterol can decrease circulatory HDL-C levels and that zinc protects against cholesterol-induced hepatic damage by reducing lysosomal enzyme release and preventing lipid peroxidation in the liver.

• OSTI ID: 5429431
• Journal Information: Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 44:25; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BLOOD SERUM
BODY
CHOLESTEROL
CYTOCHROMES
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
ENZYME ACTIVITY
ENZYMES
GLANDS
GLUCURONIDASE
GLYCOSYL HYDROLASES
HYDROLASES
HYDROXY COMPOUNDS
LIPIDS
LIPOPROTEINS
LIVER
MAMMALS
METALS
MIXED-FUNCTION OXIDASES
O-GLYCOSYL HYDROLASES
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGENASES
PIGMENTS
PROTEINS
RATS
RODENTS
STEROIDS
STEROLS
SYNTHESIS
VERTEBRATES
ZINC