Differences in Thallium-201 uptake in reperfused and nonreperfused myocardial infarction
The respective importance of flow and cellular viability in determining initial myocardial thallium uptake was studied in reperfused and nonreperfused experimental myocardial infarction. Open-chest dogs were subjected to permanent coronary artery occlusion of 70-minute (n . 3) or 5-hour duration (n . 5), or to a 3-hour temporary occlusion followed by reflow (n . 14). Thallium uptake 10 minutes after intravenous injection was compared directly with radioactive microspheres in myocardial samples from excised hearts. Triphenyl tetrazolium chloride staining was used to differentiate necrotic and viable samples with confirmation by electron microscopy. In nonreperfused infarcts, thallium uptake occurred despite necrosis, and a close correlation was found between thallium uptake and regional myocardial blood flow. In reperfused infarcts, thallium uptake again occurred, but was reduced relative to flow in necrotic myocardium and, to a lesser extent, in reperfused viable areas. However, because of the high levels of reflow, actual thallium uptake was often more than 50% of normal in reperfused necrotic regions. This study demonstrates that the presence of thallium uptake is an unreliable indicator of myocardial injury and that reperfused necrotic tissue may have remarkably high levels of thallium uptake.
- Research Organization:
- Cardiology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland
- OSTI ID:
- 5428841
- Journal Information:
- Circ. Res.; (United States), Vol. 53:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
MYOCARDIAL INFARCTION
DIAGNOSIS
MYOCARDIUM
RADIONUCLIDE KINETICS
THALLIUM 201
UPTAKE
BLOOD FLOW
DOGS
ELECTRON MICROSCOPY
EVALUATION
MICROSPHERES
PERFUSED ORGANS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HEART
HEAVY NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICROSCOPY
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
THALLIUM ISOTOPES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics