Human glutathione peroxidase activity in cases of high selenium exposures

Journal Article · Sun Jan 31 23:00:00 EST 1988 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(88)80003-3· OSTI ID:5428823

Valentine, J L; Faraji, B; Kang, H K

Four communities with water supplies having selenium concentrations of less than 3.1, 1.7, 189, and 496 micrograms/liter were selected for study. Samples of blood, urine, and tap water were obtained from participants in each community and analyzed for selenium content. Blood samples were also analyzed for glutathione peroxidase activity. Results showed an increase in selenium concentration in the urine as the water selenium increased. Selenium concentrations in blood did not reflect the increased selenium exposure. Glutathione peroxidase activity in whole blood decreased in highly exposed participants compared to those with low exposure. We conclude that glutathione peroxidase activity in cases of possible environmental toxic exposures will not show the increased activity seen in supplementation of selenium to deficient subjects.

• Research Organization: Univ. of California, Los Angeles (USA)
• OSTI ID: 5428823
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 45:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

520200 -- Environment
Aquatic-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL ACCUMULATION
CONTAMINATION
DISTRIBUTION
DRUGS
ECOLOGICAL CONCENTRATION
ELEMENTS
ENZYME ACTIVITY
ENZYMES
GLUTATHIONE
MAMMALS
MAN
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PEPTIDES
PEROXIDASES
POLLUTION
POLYPEPTIDES
PRIMATES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
SELENIUM
SEMIMETALS
TISSUE DISTRIBUTION
TOXICITY
VERTEBRATES
WATER POLLUTION
WATER SUPPLY