The effects of ozone on the respiratory epithelium of mice II: ultrastructural alterations

Journal Article · Sat Dec 01 04:00:00 EST 1979 · J. Environ. Pathol. Toxicol.; (United States)

OSTI ID:5428665

Ibrahim, A L; Zee, Y C; Osebold, J W

Ultrastructural alterations in the tracheal and bronchial epithelium of mice exposed to 0.8 ppm ozone for varying periods of time were examined with scanning electron microscopy. The lesions were apparent in the ciliated cells. Examination of tissue from control mice showed that the ciliated cells were arranged in groups and the cilia were uniform in length. After six days of exposure to ozone, shortened cilia were occasionally observed; by day 10, more pronounced changes were observed. Cilia were either absent or became short and blunt. The lesions observed after 20 days in ozone were similar to those seen on day 10. After ozone-exposed mice had been returned to ambient air for 10 days, ciliary regeneration occurred and, the major airways had a surface appearance approaching the normal state.

• Research Organization: Univ. of California, Davis
• OSTI ID: 5428665
• Journal Information: J. Environ. Pathol. Toxicol.; (United States), Journal Name: J. Environ. Pathol. Toxicol.; (United States) Vol. 3:1-2; ISSN JEPTD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BODY
BRONCHI
ELECTRON MICROSCOPY
EPITHELIUM
MAMMALS
MICE
MICROSCOPY
MORPHOLOGICAL CHANGES
OZONE
RECOVERY
RESPIRATORY SYSTEM
RODENTS
SCANNING ELECTRON MICROSCOPY
TISSUES
TRACHEA
ULTRASTRUCTURAL CHANGES
VERTEBRATES