Protection of normal tissues with 2-aminoethylisothiouronium during local pelvic radiation in monkeys
Intestinal and bladder injury are the main limiting factors to radiation therapy in patients with pelvic neoplasms. 2-Amino-ethylisothiouronium (AET) is a radiation-protective agent when given systemically but absorbs poorly from the intestines. Accordingly, it was explored for the local protection of the bowel and bladder during radiation to the pelvis. Radiation localized to the pelvis in various high fractionated doses and various schedules was applied to pairs of stumptailed monkeys (Macaca arctoides): one was always a control; and the other was treated with AET. AET was applied to the bladder through a catheter and to the rectum with a cotton tampon during the time of radiation. After radiation, AET was removed by repeated washings. Control animals developed hemorrhage, diarrhea, and emaciation and died at various times after completion of the radiation course; biopsy of rectal mucosa showed severe radiation damage. AET-treated animals had only occult blood in the stools and suffered slight weight loss; rectal biopsies showed normal tissues 2 weeks after radiation.
- Research Organization:
- Roswell Park Memorial Institute, Buffalo, New York
- OSTI ID:
- 5427925
- Journal Information:
- Cancer Res.; (United States), Vol. 43:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
AET
BIOLOGICAL EFFECTS
BLADDER
RADIATION INJURIES
INTESTINES
MONKEYS
PELVIS
RADIOTHERAPY
SIDE EFFECTS
AMINES
ANIMALS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARBONIC ACID DERIVATIVES
DIGESTIVE SYSTEM
DRUGS
GASTROINTESTINAL TRACT
INJURIES
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PRIMATES
RADIATION EFFECTS
RADIOLOGY
RADIOPROTECTIVE SUBSTANCES
THERAPY
THIOUREAS
URINARY TRACT
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
550603 - Medicine- External Radiation in Therapy- (1980-)
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)