Deposition and retention of 0. 1 micron /sup 67/Ga/sub 2/O/sub 3/ aggregate aerosols in rats following whole body exposures

Journal Article · · Fundam. Appl. Toxicol.; (United States)

OSTI ID:5427348

Wolff, R K; Griffis, L C; Hobbs, C H; McClellan, R O

Determinations were made of respiratory tract deposition and gastrointestinal tract burdens following whole body inhalation exposures, typical of those used in many chronic exposures; these were compared to values obtained in nose-only exposures. Fischer-344 rats were exposed in large volume chambers, in a whole body mode, to 0.1 micron volume median diameter (VMD) /sup 67/Ga/sub 2/O/sub 3/ particles 5 hrs/day. Deposition per unit of exposure time and retention were essentially identical following either 1 or 3 day exposures. The lung deposition of particles was 2.8 units/hr for males and 2.2 units/hr for females if the exposure concentration was expressed as 1 unit/L. These values represent a deposition of approximately 15% of the inhaled particles, similar to values obtained for nose-only exposures. Aerosol deposition per kgm body weight was 24% higher in females than males. Passage of material into the gastrointestinal tract was 1.6-fold greater for these whole body exposures as compared to nose-only exposures to the same aerosol mainly resulting from extra material ingested by grooming of the pelt. Approximately 60% of the pelt burden was calculated to be ingested following whole body exposures.

• Research Organization: Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico
• OSTI ID: 5427348
• Journal Information: Fundam. Appl. Toxicol.; (United States), Journal Name: Fundam. Appl. Toxicol.; (United States) Vol. 2:4; ISSN FAATD
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
BODY BURDEN
CHALCOGENIDES
COLLOIDS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISPERSIONS
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
FEMALES
GALLIUM 67
GALLIUM COMPOUNDS
GALLIUM ISOTOPES
GALLIUM OXIDES
GASTROINTESTINAL TRACT
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
LUNGS
MALES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PARTICLE SIZE
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RETENTION
RODENTS
SIZE
SOLS
TISSUE DISTRIBUTION
VERTEBRATES