Adrenergic receptors on cerebral microvessels in control and Parkinsonian subjects

Journal Article · Mon Aug 12 04:00:00 EDT 1985 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(85)90465-5· OSTI ID:5416380

Cash, R; Lasbennes, F; Sercombe, R; Seylaz, J; Agid, Y

The binding of adrenergic ligands (/sup 3/H-prazosin, /sup 3/H-clonidine, /sup 3/H-dihydroalprenolol) was studied on a preparation of cerebral microvessels in the prefrontal cortex and putamen of control and Parkinsonian subjects. The adrenergic receptor density in microvessels of control patients was less than 0.5% and 3.3% respectively of the total binding. A significant decrease in the number of alpha-1 binding sites was observed on microvessels in the putamen of patients with Parkinson's disease. 22 references, 2 tables.

• Research Organization: Laboratoire de Medecine Experimentale, Paris, France
• OSTI ID: 5416380
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 37:6; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHEMICAL BONDS
DISEASES
DRUGS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIGANDS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
ORGANS
PATIENTS
RECEPTORS
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS