The role of chemicals and radiation in the etiology of cancer
Book
·
OSTI ID:5415319
In this volume, investigators consider the mechanisms of oncogenesis, cell transformation, and carcinogen metabolism and present new findings on chemical and radiation carcinogenesis and chemically induced mutagenesis and chromosomal changes. As background to the studies of chemical and radiation carcinogenesis, the book surveys knowledge of cell transformation and carcinogen metabolism. Among the topics reviewed are the transforming genes involved in human malignancy, the genetics and epigenetics of neoplasia, and the single-hit and multi-hit concepts of hepatocarcinogenesis. Also examined are organ, species, and interindividual differences in carcinogen metabolism; chemical and biochemical dosimetry of genotoxic chemical exposure; and the role of pharmacokinetics and DNA dosimetry in relating in vitro to in vivo actions of N-nitroso compounds.
- OSTI ID:
- 5415319
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560154* -- Radiation Effects on Animals-- Basic Studies-- (-1987)
560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
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DOSE-RESPONSE RELATIONSHIPS
DOSIMETRY
GENES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
METABOLISM
MUTAGENESIS
MUTATIONS
NITROSO COMPOUNDS
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ORGANIC COMPOUNDS
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560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOGENESIS
CELL TRANSFORMATIONS
CHEMISTRY
CHROMOSOMAL ABERRATIONS
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
DOSIMETRY
GENES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
METABOLISM
MUTAGENESIS
MUTATIONS
NITROSO COMPOUNDS
ONCOGENES
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
RADIATION EFFECTS