Studies of the effect of toxic coal particles on model membrane systems. Progress report, July 1, 1980-August 31, 1981

Technical Report · Mon Apr 01 00:00:00 EST 1985

OSTI ID:5414954

Kurland, R J

This progress report covers work done during the period July 1, 1980 to August 31, 1981, to study the effect of polynuclear aromatic hydrocarbons (PAH) on artificial membrane systems chosen to model lung surfactant. Such PAH compounds adsorbed on flyash particles from coal combustion are of interest since they or their metabolic byproducts could be potential carcinogens. Since the composition of organic material adsorbed on flyash from fluidized bed combustion (FBC) of coal was and still is not well characterized, we chose as a model compound 2,3-dihydroxynaphthalene (2,3DHN) to represent to some extent the following relevant properties of those PAH compounds that might be particularly effective in interacting with and penetrating lung surfactant: solubility in water; solubility in hydrocarbon liquids; and its amphipathic character. This study was to determine whether PAH compounds (1) are miscible with surfactant; (2) modify the membrane structure when miscible; (3) can be transported (and at what rate) across a membrane. The detailed exposition of the results is classified by the particular instrumental technique used to achieve these objectives: surface film pressure versus area measurements; visible, UV and fluorescence spectroscopy; proton and phosphorus-31 nuclear magnetic resonance (NMR) spectroscopy. Efforts concentrated on the first of these techniques. 9 figs.

• Research Organization: State Univ. of New York, Buffalo (USA). Dept. of Chemistry
• DOE Contract Number: AC21-80MC14514
• OSTI ID: 5414954
• Report Number(s): DOE/MC/14514-1796; ON: DE85003396
• Resource Relation: Other Information: Portions of this document are illegible in microfiche products. Original copy available until stock is exhausted
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
01 COAL, LIGNITE, AND PEAT
FLY ASH
TOXICITY
LUNGS
SURFACTANTS
POLYCYCLIC AROMATIC HYDROCARBONS
COAL
COMBUSTION PRODUCTS
MEMBRANES
PHYSIOLOGY
AEROSOL WASTES
AROMATICS
ASHES
BODY
CARBONACEOUS MATERIALS
ENERGY SOURCES
FOSSIL FUELS
FUELS
HYDROCARBONS
MATERIALS
ORGANIC COMPOUNDS
ORGANS
RESIDUES
RESPIRATORY SYSTEM
WASTES
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)
016000 - Coal
Lignite
& Peat- Health & Safety