Toxicological risk assessment. Volume 1

Book · Mon Dec 31 23:00:00 EST 1984

OSTI ID:5414647

Clayson, D B; Krewski, D; Munro, I

This book contains the following chapters: Interspecies Extrapolation of Drug and Genetic Toxicity Data. Pharmacokinetic Differences Between Species. Differences in Metabolism at Different Dose Levels. Toxicological Effects on Carcinogenesis. Problems in Interspecies Extrapolation. Statistical Design and Analysis of the Long-Term Carcinogenicity. Bioassay. Statistical Analysis of Rodent Tumorigenicity Experiments. Use of the Hartley-Sielken Model in Low-Dose Extrapolation. Review of Methods for Calculating Statistical Confidence Limits in Low-Dose Extrapolation. Incorporation of Pharmacokinetics in Low-Dose Risk Estimation.

• OSTI ID: 5414647
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
CARCINOGENESIS
CARCINOGENS
DOSE-RESPONSE RELATIONSHIPS
DOSES
DRUGS
EXTRAPOLATION
IRRADIATION
KINETICS
LOW DOSE IRRADIATION
MAMMALS
MATHEMATICAL MODELS
MATHEMATICS
METABOLISM
NUMERICAL SOLUTION
PATHOGENESIS
PHARMACOLOGY
REACTION KINETICS
RISK ASSESSMENT
RODENTS
SPECIES DIVERSITY
STATISTICAL MODELS
STATISTICS
TOXICITY
VERTEBRATES