Purification and characterization of porcine growth hormone-dependent insulin-like growth factor binding protein
Thesis/Dissertation
·
OSTI ID:5413547
The objectives of this thesis were (1) to evaluate molecular weight (M{sub r}) profiles of IGF-I and {sup 125}I-IGF-I; binding activity in pig serum; (2) to determine whether exogenous IGF-I partitions to IGFBPs in the circulation in pigs; (3) to purify and characterize the GH-dependent IGFBP from pig serum; (4) to assess the effects of the IGFBP on IGF-I action in vitro; (5) to establish a radioimmunoassay for the IGFBP; and (6) to measure IGFBP concentrations in serum from GH- and IGF-I-treated pigs.
- Research Organization:
- Pennsylvania State Univ., University Park, PA (USA)
- OSTI ID:
- 5413547
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOASSAY
BIOCHEMICAL REACTION KINETICS
BLOOD SERUM
CHEMICAL COMPOSITION
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
FRACTIONATION
GROWTH FACTORS
HORMONES
IMMUNOASSAY
IMMUNOLOGY
INSULIN
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MAMMALS
MITOGENS
MOLECULAR WEIGHT
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
RADIOISOTOPES
REACTION KINETICS
SEPARATION PROCESSES
SWINE
TRACER TECHNIQUES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOASSAY
BIOCHEMICAL REACTION KINETICS
BLOOD SERUM
CHEMICAL COMPOSITION
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
FRACTIONATION
GROWTH FACTORS
HORMONES
IMMUNOASSAY
IMMUNOLOGY
INSULIN
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MAMMALS
MITOGENS
MOLECULAR WEIGHT
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
RADIOISOTOPES
REACTION KINETICS
SEPARATION PROCESSES
SWINE
TRACER TECHNIQUES
VERTEBRATES