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Effects of nitrogen dioxide on pulmonary function in human subjects: an environmental chamber study

Journal Article · · Environ. Res.; (United States)
; ; ;

Twenty human subjects with asthma and chronic bronchitis and 10 normal, healthy adults were exposed to 0.5 ppM of nitrogen dioxide for 2 h in an environmental chamber. Seven of the 13 subjects with asthma experienced symptoms with exposure, while only one each of the subjects with chronic bronchitis and the healthy, normal group experienced symptoms. Significant pulmonary function changes from control values with exposure to NO/sub 2/ were observed in decreased quasistatic compliance for the 10 normal subjects and the 20 subjects with asthma and chronic bronchitis. In addition, functional residual capacity increased significantly for the 20 subjects with asthma and chronic bronchitis. The subjects with asthma and the subjects with chronic bronchitis as separate groups, however, did not show any significant changes with exposure. With this study we are reasonably confident that exposure of subjects with asthma and chronic bronchitis to 0.5 ppM NO/sub 2/ for 2 h does not produce a significant decrement in their pulmonary function.

Research Organization:
Univ. of Maryland School of Medicine, Baltimore
OSTI ID:
5413346
Journal Information:
Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 19:2; ISSN ENVRA
Country of Publication:
United States
Language:
English

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Related Subjects

551000 -- Physiological Systems
552000 -- Public Health
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AEROSOLS
ASTHMA
BIOLOGICAL EFFECTS
BODY
BRONCHITIS
CHALCOGENIDES
COLLOIDS
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DISEASES
DISPERSIONS
DYNAMIC FUNCTION STUDIES
EXPERIMENTAL DATA
EXPOSURE CHAMBERS
INFORMATION
ISOLATED VALUES
LUNGS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATIENTS
RESIDUES
RESPIRATION
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RESPONSE MODIFYING FACTORS
SMOKES
SOLS
TOBACCO SMOKES
TOXICITY