Noninvasive quantitation of myocardial blood flow in human subjects with oxygen-15-labeled water and positron emission tomography

Journal Article · Fri Sep 01 00:00:00 EDT 1989 · Journal of the American College of Cardiology; (USA)

DOI:https://doi.org/10.1016/0735-1097(89)90105-8· OSTI ID:5411536

Bergmann, S R; Herrero, P; Markham, J; Weinheimer, C J; Walsh, M N ^[1]

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1. Washington Univ. School of Medicine, St. Louis, MO (USA)

Noninvasive measurement of myocardial blood flow in absolute terms (i.e., milliliters per gram per min) has been difficult to accomplish despite the intrinsically quantitative power of positron emission tomography because of the nonphysiologic nature of tracers that have been employed conventionally as well as the limited spatial resolution of currently available instruments. It was previously demonstrated that myocardial blood flow in animals can be quantitated accurately with the diffusible tracer oxygen-15-labeled water (H2(15)O) when the arterial input function and myocardial radiotracer concentration were measured directly. To extend the approach for completely noninvasive measurement of blood flow, a parameter estimation procedure was developed whereby effects of limited tomographic spatial resolution and cardiac motion were compensated for within the operational flow model. In validation studies in 18 dogs, myocardial blood flow measured with positron emission tomography after intravenously administered H2(15)O correlated closely with flow measured with concomitantly administered radiolabeled microspheres over the range of 0.29 to 5.04 ml/g per min (r = 0.95). Although regional ischemia was clearly identifiable tomographically, absolute flow could not be determined accurately in ischemic regions in four dogs because of poor count statistics related to wall thinning. Subsequently, myocardial blood flow was measured in 11 normal human subjects. Flow was homogeneous throughout the myocardium, averaged 0.90 +/- 0.22 ml/g per min at rest and increased to 3.55 +/- 1.15 ml/g per min after intravenous administration of dipyridamole. Therefore, positron emission tomography with H2 15O and the approach developed permits noninvasive measurement of myocardial blood flow in absolute terms in humans and should facilitate objective assessment of interventions designed to enhance nutritive perfusion.

• OSTI ID: 5411536
• Journal Information: Journal of the American College of Cardiology; (USA), Vol. 14:3; ISSN 0735-1097
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
HEART
POSITRON COMPUTED TOMOGRAPHY
ISCHEMIA
DIAGNOSIS
MYOCARDIUM
BLOOD FLOW
INTRAVENOUS INJECTION
MAN
MICROSPHERES
OXYGEN 15
SPATIAL RESOLUTION
VASODILATORS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
INJECTION
INTAKE
ISOTOPES
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
MUSCLES
NUCLEI
ORGANS
OXYGEN ISOTOPES
PRIMATES
RADIOISOTOPES
RESOLUTION
TOMOGRAPHY
VASCULAR DISEASES
VERTEBRATES
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