Triiodothyronine improves the primary antibody response to sheep red blood cells in severely undernourished weanling mice

Journal Article · Tue Sep 01 00:00:00 EDT 1987 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-185-42565· OSTI ID:5409812

Filteau, S M; Perry, K J; Woodward, B

Three experiments were conducted in which weanling mice were fed a nutritionally complete diet either ad libitum or in restricted quantities such that they lost about 30% of their initial weight over a 14-day period. In Experiments 1 and 2, half the animals from each group received dietary triiodothyronine (T/sub 3/) supplements. In Experiment 3, food-intake-restricted mice were fed graded levels of potassium iodide. Malnutrition reduced the number of nucleated cells per spleen, the number of splenic IgG plaque-forming cells (PFC) per 10/sup 6/ cells, and the serum antibody titers against sheep red blood cells as determined by radioimmunoassay. T/sub 3/ supplements increased antibody titers, the number of nucleated cells per spleen, and both IgM and IgG PFC per 10/sup 6/ spleen cells in malnourished mice, but had no effect on well-nourished mice. The beneficial effect of T/sub 3/ was not a result of improved protein, energy, or iodine status in the malnourished mice.

• Research Organization: Univ. of Guelph, Ontario (Canada)
• OSTI ID: 5409812
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Vol. 185:4
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ERYTHROCYTES
IMMUNE REACTIONS
TRIIODOTHYRONINE
BIOLOGICAL EFFECTS
ANTIBODIES
CELL NUCLEI
DIET
FASTING
MICE
NUTRITIONAL DEFICIENCY
RADIOIMMUNOASSAY
SPLEEN CELLS
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CONSTITUENTS
HORMONES
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
MAMMALS
MATERIALS
PEPTIDE HORMONES
RADIOASSAY
RADIOIMMUNOLOGY
RODENTS
SOMATIC CELLS
THYROID HORMONES
TRACER TECHNIQUES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques