Sources and evolution of human Alu repeated sequences

Journal Article · Fri Jul 01 00:00:00 EDT 1988 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.85.13.4770· OSTI ID:5404948

Britten, R J; Baron, W F; Stout, D B; Davidson, E H ^[1]

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1. California Institute of Technology, Pasadena (USA)

Alu repeated sequences arising in DNA of the human lineage during about the last 30 million years are closely similar to a modern consensus. Alu repeats arising at earlier times share correlated blocks of differences from the current consensus at diagnostic positions in the sequence. Using these 26 positions, the authors can recognize four subfamilies and the older ones are each successively closer to the 7SL sequence. It appears that there has existed a series of conserved genes that are the primary sources of the Alu repeat family, presumably through retroposition. These genes have probably replaced each other in overlapping relays during the evolution of primates.

• OSTI ID: 5404948
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (USA) Vol. 85:13; ISSN 0027-8424; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL EVOLUTION
DISEASES
DNA
DNA SEQUENCING
ETIOLOGY
GENE MUTATIONS
GENE RECOMBINATION
GENES
HEREDITARY DISEASES
HUMAN POPULATIONS
MAMMALS
MAN
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
POPULATIONS
PRIMATES
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES