Multimodality treatment of patients with advanced ovarian carcinoma

Journal Article · Fri Oct 01 04:00:00 EDT 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(82)90285-1· OSTI ID:5404368

Pino y Torres, J L ^[1]; Bross, D S; Hernandez, E; Rosenshein, N; Klein, J L; Ettinger, D S; Leichner, P K; Order, S E

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1. Johns Hopkins Hospital, Baltimore, MD

A multimodality treatment program has been applied to ovarian carcinoma at the Johns Hopkins Hospital since August 1975. Forty-nine patients were subdivided into 23 patients with maximally respected Stage III micrometastatic, and 26 patients with significant retained disease, 20 with Stage III macrometastic and 6 with STage IV. After initial pilot studies, those patients with minimally retained disease entered a randomized prospective study. Antiovarian antiserum was used in one arm of the study; in both study arms colloidal P-32, delayed split whole abdominal irradiation, and maintenance melphalan were used. For the 23 patients with micrometastiatic disease the cumulative survival and survival without evidence of disease at four years is 78 and 34% respectively. Twenty-six patients with macrometastatic disease were treated with or witout intraperitoneal antiserum and multiagent chemotherapy; their cummulative one year survival is 50%. The lack of significant toxicity of intraperitoneal antiovarian antiserum and the results of multimodality therapy indicate the feasibility of this therapeutic approach to further improve ovarian cancer therapy.

• OSTI ID: 5404368
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:10; ISSN IOBPD
• Country of Publication: United States
• Language: English

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550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ABDOMEN
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
CARCINOMAS
CHEMOTHERAPY
COLLOIDS
DAYS LIVING RADIOISOTOPES
DISEASES
DISPERSIONS
EVALUATION
FEMALE GENITALS
GONADS
IMMUNE SERUMS
IMMUNOTHERAPY
ISOTOPES
LIGHT NUCLEI
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
OVARIES
PATIENTS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
RADIOCOLLOIDS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
THERAPY