Chromatin structural changes precede replication in initiated replicons during inhibition of DNA elongation
Conference
·
OSTI ID:5404292
Partial inhibition of replicative DNA synthesis by hydroxyurea or other agents produces changes in the composition and structure of bulk chromatin. We have begun to investigate the structural changes in specific regions of the genome using synchronized cells and cloned genomic probes. Current results indicate changes in chromatin structure occur preferentially in initiated replicons and can precede the replication fork during inhibition of DNA elongation. 4 refs., 2 figs.
- Research Organization:
- Los Alamos National Lab., NM (USA)
- DOE Contract Number:
- W-7405-ENG-36
- OSTI ID:
- 5404292
- Report Number(s):
- LA-UR-88-266; CONF-880157-2; ON: DE88005395
- Country of Publication:
- United States
- Language:
- English
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