ADP-ribosylation of proteins: Enzymology and biological significance
This book presents an overview of the molecular and biological consequences of the posttranslational modification of proteins with ADP-ribose monomers and polymers. Part one focuses on chromatin-associated poly ADP-ribosylation reactions which have evolved in higher eukaryotes as modulators of chromatin functions. The significance of poly ADP-ribosylation in DNA repair, carcinogenesis, and gene expression during terminal differentiation is discussed. Part two reviews mono ADP-ribosylation reactions which are catalyzed by prokaryotic and eukaryotic enzymes. Consideration is given to the action of bacterial toxins, such as cholera toxin, pertussis toxin, and diphtheria toxin. These toxins have emerged as tools for the molecular probing of proteins involved in signal transduction and protein biosynthesis.
- OSTI ID:
- 5404227
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
DNA REPAIR
BIOLOGICAL PATHWAYS
POST-TRANSLATION MODIFICATION
MOLECULAR BIOLOGY
PROTEINS
BIOSYNTHESIS
ADP
CARCINOGENESIS
CELL DIFFERENTIATION
ENZYME ACTIVITY
GENES
PHENOTYPE
PROBES
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
NUCLEOTIDES
ORGANIC COMPOUNDS
PATHOGENESIS
RECOVERY
REPAIR
SYNTHESIS
550200* - Biochemistry