Radioimmunodetection of lymph node invasion in prostatic cancer. The use of iodine-123 ( sup 123 I)-labeled monoclonal anti-prostatic acid phosphatase (PAP) 227 A F(ab')2 antibody fragments in vivo

Journal Article · Sat Jul 01 04:00:00 EDT 1989 · Cancer (Philadelphia); (USA)

DOI:https://doi.org/10.1002/1097-0142(19890701)64:1<1::AID-CNCR2820640102>3.0.CO;2-2· OSTI ID:5403795

Leroy, M; Teillac, P; Rain, J D; Saccavini, J C; Le Duc, A; Najean, Y ^[1]

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1. Service de Medecine Nucleaire, Paris (France)

The therapeutic indications in prostatic cancer depend on the regional and distant extension of the cancer and are difficult to assess before lymphadenectomy. Radioimmunodetection of lymph node involvement with monoclonal anti-prostatic acid phosphatase (PAP) antibodies can be proposed as a noninvasive alternative to lymphadenectomy. Fifteen patients with various stages of histologically proven prostatic cancer were examined by immunolymphoscintigraphy (ILS) before treatment to detect lymph node metastases. These patients had Stage A (n = 7), Stage B (n = 3), Stage C (n = 2), and Stage D (n = 3) tumors. They received between 100 and 400 micrograms of monoclonal antibody 227 A in the form of F(ab')2 fragments labeled with iodine-123 ({sup 123}I). The antibody was injected directly into the periprostatic area. ILS images were obtained after 1, 3, 6, and 24 hours. Three days later, each patient underwent a lymphadenectomy for histologic examination. The results of the histologic examination and ILS were compared. In ten patients, the examination did not show any images capable of being interpreted as lymphadenopathy and histologic examination confirmed the integrity of the nodes examined. In five cases, scintigraphy suggested the presence of lymph node invasion by prostatic cancer and this was confirmed by histologic examination in three of the five cases. Overall, in terms of lymphadenopathy, this examination had a sensitivity of 100% and a specificity of 83%. Therefore, ILS appears to be capable of detecting lymph node metastases in prostatic cancer.

• OSTI ID: 5403795
• Journal Information: Cancer (Philadelphia); (USA), Journal Name: Cancer (Philadelphia); (USA) Vol. 64:1; ISSN 0008-543X; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ACID PHOSPHATASE
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ENZYMES
ESTERASES
GLANDS
GLOBULINS
HOURS LIVING RADIOISOTOPES
HYDROLASES
IMMUNOGLOBULINS
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LYMPH NODES
LYMPHATIC SYSTEM
MALE GENITALS
MAMMALS
MAN
METASTASES
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PHOSPHATASES
PRIMATES
PROSTATE
PROTEINS
RADIOIMMUNODETECTION
RADIOIMMUNOSCINTIGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SENSITIVITY ANALYSIS
TRACER TECHNIQUES
VERTEBRATES