Ultraviolet-induced photochemical damage in the ocular tissues. Final report

Technical Report · Mon May 01 04:00:00 EDT 1989

OSTI ID:5401634

Zuclich, J A

Exposure to ultraviolet lasers may result in pathology to either the cornea, lens, or retina of the primate eye. The particular combination of exposure parameters (wavelength, peak power, pulsewidth, pulse repetition rate and total energy delivered) determine the target tissue(s) in each instance. The effect may be acute or chronic, and the implicated damage mechanism categorized as photochemical, photoablative or thermal. This discussion summarizes a number of specific cases where ultraviolet-laser radiation affected the cornea, lens and/or retina; will describe the nature of the pathologies; and will indicate what is known about the damage mechanisms in each case. Ranges of exposure parameters where each ocular tissue is the most sensitive will be defined. Data discussed include the action spectra for far- and near-ultraviolet induced ocular damage; the pulse width and total energy dependencies of corneal and lens thresholds; cumulative effects of repeated ultraviolet exposures and repair or recovery rates. Finally, retinal photoreceptor damage resulting from near-UV laser exposures is described. This apparent photochemical effect was observed following exposure to a 325-nm helium cadmium laser when 0.28 J was delivered to the eye.

• Research Organization: Krug International, San Antonio, TX (USA). Technology Services Div.
• OSTI ID: 5401634
• Report Number(s): AD-A-209902/6/XAB
• Country of Publication: United States
• Language: English

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