In vivo chemistry of iofetamine HCl iodine-123 (IMP)
Application of chemical methods for characterizing the in vivo behavior of iofetamine HCI /sup 123/I (IMP) has shed light on the metabolism of iofetamine in animals and humans. A successful technique consists of ethyl acetate extraction of the metabolites from tissue samples acidified with perchloric acid, separation of the mixture by high performance liquid chromatography, and quantitation of the radioactive components with a sensitive scintillation detector. Metabolism of iofetamine HCI /sup 123/I proceeds sequentially from the N-isopropyl group on the amphetamine side chain. The first step, dealkylation to the primary amine p-iodoamphetamine (PIA), occurs readily in the brain, lungs, and liver; activity in the brain and lungs consists of only IMP and PIA even 24 hr after administration. The rate-limiting step appears to be deamination to give the transitory intermediate p-iodophenylacetone, which is rapidly degraded to p-iodobenzoic acid and conjugated with glycine in the liver to give the end product of metabolism, p-iodohippuric acid, which is excreted through the kidneys in the urine.
- Research Organization:
- Medi-Physics, Inc., Emeryville CA
- OSTI ID:
- 5401368
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 29:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
AMPHETAMINES
METABOLISM
TISSUE DISTRIBUTION
BRAIN
DEAMINATION
IN VIVO
IODINE 123
LIQUID COLUMN CHROMATOGRAPHY
LIVER
SCINTILLATION COUNTING
TRACER TECHNIQUES
ANALEPTICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CHEMICAL REACTIONS
CHROMATOGRAPHY
COUNTING TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
SEPARATION PROCESSES
SYMPATHOMIMETICS
550501* - Metabolism- Tracer Techniques