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Pentavalent (/sup 99m/Tc)DMSA, (/sup 131/I)MIBG, and (/sup 99m/Tc)MDP--an evaluation of three imaging techniques in patients with medullary carcinoma of the thyroid

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:5400946
; ; ; ;

Nine patients with histologically proven medullary carcinoma of the thyroid (MCT) were imaged using pentavalent (/sup 99m/Tc)dimercaptosuccinic acid ((V)DMSA), (/sup 131/I) metaiodobenzylguanidine (MIBG) and (/sup 99m/Tc)methylene diphosphonate (MDP). Technetium-99m (V)DMSA demonstrated most of the tumor sites in eight patients with proven metastases, with an overall sensitivity of 95% in lesion detection. Iodine-131 MIBG showed definite uptake in some of the tumor sites in three of the nine patients imaged, with equivocal uptake seen in a further one patient, with sensitivity of only 11% for lesion detection. Technetium-99m MDP demonstrated bony metastases only, in four of the patients imaged yielding a sensitivity of 61%. Technetium-99m (V)DMSA has been demonstrated in this study to be a useful imaging agent in patients with MCT, showing uptake in significantly more lesions and with better imaging qualities than (/sup 131/I)MIBG, and with the ability to detect soft tissue as well as bony metastases.

Research Organization:
Guy's Hospital, London, England
OSTI ID:
5400946
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 29:1; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARCINOMAS
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
ENDOCRINE GLANDS
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
ORGANS
PATIENTS
RADIOISOTOPES
SENSITIVITY ANALYSIS
TECHNETIUM 99
TECHNETIUM ISOTOPES
THYROID
TRACER TECHNIQUES
YEARS LIVING RADIOISOTOPES