Development of pretreatment compounds against nerve-gas agents. Annual report (Final), 16 May 88-30 Sep 90
The U. S. Army Medical Research and Development Command is interested in research directed toward the development of countermeasures to chemical warfare (CW) agents such as the nerve gas poison soman. Soman and other nerve gas poisons are extremely potent cholinesterase inhibitors. This inhibition leads to a buildup of excess acetylcholine resulting in over-stimulation of both the peripheral and central nervous system and can lead to death. Standard therapy for organophosphate nerve agent poisoning is based on co-administration of an anticholinergic agent such as atropine to antagonize the effects of accumulated acetylcholine and a cholinesterase reactivator such as 2-PAM to dephosphorylate the inhibited enzyme. However, since many problems remain in the treatment of organophosphate nerve agent poisoning, there is considerable interest and need to develop new pretreatment and treatment drugs, particularly for soman poisoning.
- Research Organization:
- Research Triangle Inst., Durham, NC (United States)
- OSTI ID:
- 5398934
- Report Number(s):
- AD-A-233691/5/XAB; CNN: DAMD17-88-C-8115
- Country of Publication:
- United States
- Language:
- English
Similar Records
Nerve agent intoxication: Recent neuropathophysiological findings and subsequent impact on medical management prospects
Behavioral efficacy of diazepam against nerve agent exposure in rhesus monkeys. (Reannouncement with new availability information)
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
CHEMICAL WARFARE AGENTS
INHIBITION
US DOD
RESEARCH PROGRAMS
ACETYLCHOLINE
ATROPINE
CENTRAL NERVOUS SYSTEM
CHOLINESTERASE
DEATH
DRUGS
ENZYMES
PHOSPHORYLATION
POISONING
STIMULATION
THERAPY
ALKALOIDS
AMINES
AMMONIUM COMPOUNDS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARBOXYLESTERASES
CHEMICAL REACTIONS
ESTERASES
ESTERS
HYDROLASES
NATIONAL ORGANIZATIONS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
PARASYMPATHOLYTICS
PARASYMPATHOMIMETICS
QUATERNARY COMPOUNDS
US ORGANIZATIONS
WEAPONS
450600* - Military Technology
Weaponry
& National Defense- Chemical & Biological- (1990)
551000 - Physiological Systems