Detection of preclinical Parkinson's disease with PET

Journal Article · Wed May 01 04:00:00 EDT 1991 · Neurology; (United States)

DOI:https://doi.org/10.1212/WNL.41.5_Suppl_2.24· OSTI ID:5397845

Brooks, D J ^[1]

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1. MRC Cyclotron Unit, Hammersmith Hospital, London, (United Kingdom)

Putamen 18F-dopa uptake of patients with Parkinson's disease (PD) is reduced by at least 35% at onset of symptoms; therefore, positron-emission tomography (PET) can be used to detect preclinical disease in clinically unaffected twins and relatives of patients with PD. Three out of 6 monozygotic and 2 out of 3 dizygotic unaffected PD co-twins have shown reduced putamen 18F-dopa uptake to date. In addition, an intact sibling and a daughter of 1 of 4 siblings with PD both had low putamen 18F-dopa uptake. These preliminary findings suggest there may be a familial component to the etiology of PD. PET can also be used to detect underlying nigral pathology in patients with isolated tremor and patients who become rigid taking dopamine-receptor blocking agents (DRBAs). Patients with familial essential tremor have normal, and those with isolated rest tremor have consistently low, putamen 18F-dopa uptake. Drug-induced parkinsonism is infrequently associated with underlying nigral pathology.

• OSTI ID: 5397845
• Journal Information: Neurology; (United States), Journal Name: Neurology; (United States) Vol. 41:5 Suppl 2; ISSN 0028-3878; ISSN NEURA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
AMINO ACIDS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOPA
DOPAMINE
DRUGS
EMISSION COMPUTED TOMOGRAPHY
FLUORINE 18
FLUORINE ISOTOPES
HEREDITARY DISEASES
HOURS LIVING RADIOISOTOPES
HYDROXY ACIDS
HYDROXY COMPOUNDS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIGHT NUCLEI
MEMBRANE PROTEINS
NANOSEC LIVING RADIOISOTOPES
NERVOUS SYSTEM DISEASES
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATIENTS
PHENOLS
POLYPHENOLS
POSITRON COMPUTED TOMOGRAPHY
PROTEINS
RADIOISOTOPES
RECEPTORS
SYMPATHOMIMETICS
TOMOGRAPHY