Preparation and characterization of nitrogen-sulfur donor ligands and their technetium complexes
Thesis/Dissertation
·
OSTI ID:5396985
Technetium complexes of bidentate aminoethanethiol and tetradentate bis-aminoethanethiol ligands were studied to determine the charge, stoichiometry, lipid solubility, stability, and structure of the complexes, technetium-99m and technetium-99 were used in a complementary fashion to obtain the information necessary to determine the suitability of using these ligands for incorporation into biologically interesting compounds for radiotracer development. Bidentate aminoethanethiol ligands form bis complexes with technetium of the general form: TcOXL/sub 2/. These complexes is stable in solution; however, they rapidly exchange with 1,2-ethanedithiol to form the bis(ethanedithiolato) complex. Tetradentate bis-aminoethanethiol ligands form 1:1 complexes with technetium of the general form: TcOXL. These complexes are also stable in solution and exchange very slowly with 1,2-ethanedithiol. The synthesis of the ligands and complexes are described and the implications of the results obtained on radiotracer development are discussed.
- Research Organization:
- Johns Hopkins Univ., Baltimore, MD (USA)
- OSTI ID:
- 5396985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHEMICAL PREPARATION
COMPLEXES
ELEMENTS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGANDS
LIPIDS
MOLECULAR STRUCTURE
NITROGEN
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
RADIOISOTOPES
SOLUBILITY
STABILITY
STOICHIOMETRY
SULFUR
SYNTHESIS
TECHNETIUM 99
TECHNETIUM COMPLEXES
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPLEXES
YEARS LIVING RADIOISOTOPES
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHEMICAL PREPARATION
COMPLEXES
ELEMENTS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGANDS
LIPIDS
MOLECULAR STRUCTURE
NITROGEN
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
RADIOISOTOPES
SOLUBILITY
STABILITY
STOICHIOMETRY
SULFUR
SYNTHESIS
TECHNETIUM 99
TECHNETIUM COMPLEXES
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPLEXES
YEARS LIVING RADIOISOTOPES