Detection and cellular localization of lead by electron probe analysis in the diagnosis of suspected lead poisoning in rhesus monkeys
Journal Article
·
· Toxicologic Pathology; (United States)
OSTI ID:5394911
- Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland (USA)
Lead poisoning of unknown source was diagnosed histologically in 2 rhesus monkeys (Macaca mulatta) by finding acid-fast intranuclear inclusion bodies in the epithelial cells of renal cortical tubules. The presence of lead in the inclusions was determined by scanning electron microscopy/energy dispersive x-ray analysis using sections from paraffin embedded tissues. This observation indicates the usefulness of this technique for the detection and cellular localization of lead in tissues, even from archival material.
- OSTI ID:
- 5394911
- Journal Information:
- Toxicologic Pathology; (United States), Journal Name: Toxicologic Pathology; (United States) Vol. 19:1; ISSN TOPAD; ISSN 0192-6233
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
560300* -- Chemicals Metabolism & Toxicology
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BODY
CHEMICAL ANALYSIS
DISTRIBUTION
ELECTRON MICROPROBE ANALYSIS
ELECTRON MICROSCOPY
ELEMENTS
EPITHELIUM
KIDNEYS
LEAD
MAMMALS
METABOLISM
METALS
MICROANALYSIS
MICROSCOPY
MONKEYS
NONDESTRUCTIVE ANALYSIS
ORGANS
PRIMATES
SCANNING ELECTRON MICROSCOPY
TISSUE DISTRIBUTION
TISSUES
TOXICITY
TUBULES
VERTEBRATES
560300* -- Chemicals Metabolism & Toxicology
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BODY
CHEMICAL ANALYSIS
DISTRIBUTION
ELECTRON MICROPROBE ANALYSIS
ELECTRON MICROSCOPY
ELEMENTS
EPITHELIUM
KIDNEYS
LEAD
MAMMALS
METABOLISM
METALS
MICROANALYSIS
MICROSCOPY
MONKEYS
NONDESTRUCTIVE ANALYSIS
ORGANS
PRIMATES
SCANNING ELECTRON MICROSCOPY
TISSUE DISTRIBUTION
TISSUES
TOXICITY
TUBULES
VERTEBRATES