Creatine kinase MB isoenzyme in dermatomyositis: a noncardiac source
Three patients with polymyositis had elevated serum levels of creatine kinase MB isoenzyme. The presence of this isoenzyme is used extensively to diagnose myocardial infarction, but the isoenzyme is also found in sera of patients with primary muscular and neuromuscular disorders. Researchers studied cardiac function in two of our patients with electrocardiograms, technetium stannous pyrophosphate scanning, and technetium 99m-labeled erythrocyte gated blood pool imaging and in the third patient by postmortem examination. There was no evidence of myocardial involvement to account for the high serum levels of isoenzyme. Creatine kinase MB in the sera of patients with polymyositis does not necessarily indicate myocardial necrosis.
- OSTI ID:
- 5394263
- Journal Information:
- Ann. Intern. Med.; (United States), Vol. 94:3
- Country of Publication:
- United States
- Language:
- English
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BLOOD SERUM
QUANTITATIVE CHEMICAL ANALYSIS
ISOENZYMES
ENZYME ACTIVITY
MYOCARDIAL INFARCTION
DIAGNOSIS
COMPARATIVE EVALUATIONS
DIAGNOSTIC USES
ERYTHROCYTES
HEART
LABELLED COMPOUNDS
MUSCLES
NECROSIS
PATHOLOGY
PATIENTS
PHOSPHOTRANSFERASES
SCINTISCANNING
TECHNETIUM 99
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEMICAL ANALYSIS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
ENZYMES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGICAL CHANGES
PHOSPHORUS-GROUP TRANSFERASES
RADIOISOTOPE SCANNING
RADIOISOTOPES
TECHNETIUM ISOTOPES
TRANSFERASES
USES
YEARS LIVING RADIOISOTOPES
550201* - Biochemistry- Tracer Techniques
550901 - Pathology- Tracer Techniques