No evidence for association of dopamine D2 receptor variant (Ser311/Cys311) with major psychosis

Journal Article · Fri Jul 26 04:00:00 EDT 1996 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/(SICI)1096-8628(19960726)67:4<415::AID-AJMG18>3.0.CO;2-M· OSTI ID:539395

Sasaki, Tsukasa; Macciardi, F M; Badri, F ^[1]

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1. Clarke Institute of Psychiatry, Ontario (Canada); and others

We investigated a variant of the dopamine D2 receptor gene (Ser311/Cys311 substitution) in Caucasian patients with schizophrenia (n = 273), delusional disorder (n = 62), bipolar I affective disorder (n = 63), and controls (n = 255). No evidence for association between the receptor variant and any of the diseases was found, even when patients with younger age-of-onset (<25 years) were compared with controls. Futhermore, in a subgroup of schizophrenia patients whom we assessed for negative symptoms, those with the Cys allele did not differ from the remainder of the group. Also, the bipolar affective disorder patients with psychotic features did not show evidence for association with the receptor variant. Thus, our results do not provide evidence for an association between this D2 receptor variant and schizophrenia, or delusional disorder, or bipolar affective disorder. 11 refs., 1 tab.

• OSTI ID: 539395
• Journal Information: American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 4 Vol. 67; ISSN 0148-7299; ISSN AJMGDA
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
AMINO ACIDS
BEHAVIOR
DOPAMINE
GENE MUTATIONS
HEREDITARY DISEASES
MENTAL DISORDERS
NERVOUS SYSTEM DISEASES
PATIENTS
RECEPTORS
STATISTICS