Long-range restriction map of the terminal part of the short arm of the human X chromosome

Journal Article · Tue May 01 00:00:00 EDT 1990 · Proceedings of the National Academy of Sciences of the United States of America; (United States)

DOI:https://doi.org/10.1073/pnas.87.10.3680· OSTI ID:5393232

Petit, C; Levilliers, J; Weissenbach, J ^[1]

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1. Institut Pasteur, Paris (France)

The terminal part of the short arm of the human X chromosome has been mapped by pulsed-field gel electrophoresis (PFGE). The map, representing the distal two-thirds of Xp22.3 spans a total of 10,000 kilobases (kb) from Xpter to the DXS143 locus. A comparison with linkage data indicates that 1 centimorgan (cM) in this region corresponds to about 600 kb. CpG islands were essentially concentrated in the 1,500 kb immediately proximal to the pseudoautosomal boundary. Several loci, including the gene encoding steroid sulfatase (STS) and the loci for the X-linked recessive form of chondrodysplasia punctata (CDPX) and for Kallmann syndrome (KAL) have been placed relative to the Xp telomere. CDPX is located between 2,650 and 5,550 kb from Xpter, and STS is located between 7,250 and 7,830 kb from Xpter. KAL maps to an interval of 350 kb between 8,600 and 8,950 kb from the telomere. The X-chromosomal breakpoints of a high proportion of XX males resulting from X-Y interchange cluster to a 920-kb region proximal and close to the pseudoautosomal boundary.

• OSTI ID: 5393232
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (United States), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (United States) Vol. 87:10; ISSN 0027-8424; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMES
CONNECTIVE TISSUE CELLS
DISEASES
DNA HYBRIDIZATION
ELECTROPHORESIS
GENETIC MAPPING
HEREDITARY DISEASES
HETEROCHROMOSOMES
HUMAN X CHROMOSOME
HYBRIDIZATION
LEUKOCYTES
LYMPHOCYTES
MAPPING
MATERIALS
PATIENTS
SOMATIC CELLS
X CHROMOSOME