Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine
Journal Article
·
· Ann. Neurol.; (United States)
Regional cerebral blood flow (rCBF) was measured in 254 areas of a hemisphere with the xenon 133 intraarterial injection method. Six cases of classic migraine were followed from the normal state into the prodromal phase, and in 3 cases further into the headache phase. One patient with common migraine was similarly followed during his only classic attack. The attacks were initiated by focal hyperemia in 3 patients. During prodromes all patients displayed occipitoparietal rCBF reduction (oligemia), but in only 1 case did the reduction approach critical values. Oligemia gradually spread anteriorly in the course of 15 to 45 minutes. In 4 patients a global oligemia was observed. In 4 patients severe headache was present concomitantly with oligemia and with no sign of hyperemia or nonhomogeneous brain perfusion. The normal rCBF increase during cortical activity (hand movement, speech, and similar activities) was impaired in 6 patients. The results indicate that the vasospastic model of the migraine attack is too simplistic.
- OSTI ID:
- 5392736
- Journal Information:
- Ann. Neurol.; (United States), Journal Name: Ann. Neurol.; (United States) Vol. 9:4; ISSN ANNED
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BODY AREAS
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CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC USES
EVEN-ODD NUCLEI
HEAD
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
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MEASURING METHODS
NERVOUS SYSTEM
NUCLEI
ORGANS
PAIN
PATHOLOGY
PATIENTS
PERFUSED TISSUES
RADIOISOTOPES
SYMPTOMS
TIME DEPENDENCE
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XENON 133
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550901 -- Pathology-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BODY AREAS
BRAIN
CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC USES
EVEN-ODD NUCLEI
HEAD
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEASURING METHODS
NERVOUS SYSTEM
NUCLEI
ORGANS
PAIN
PATHOLOGY
PATIENTS
PERFUSED TISSUES
RADIOISOTOPES
SYMPTOMS
TIME DEPENDENCE
TISSUES
USES
XENON 133
XENON ISOTOPES