Carboranyl amino acids for the specific neutron capture therapy of malignant melanoma

Technical Report · Tue Jan 15 04:00:00 EST 1991

OSTI ID:5391334

Kahl, S B

We are pleased to summarize the very significant progress made since our last report dated April 6, 1990. Significant progress has been made toward our twin objectives of both the steroselective and non-steroselective synthesis of carborane-containing amino acids for boron neutron capture therapy of malignant melanoma. Additionally, we have developed a new, general procedure for the synthesis of a variety of {alpha}-amino acids which may find wide applicability in this area. 8 refs., 5 figs., 1 tab.

• Research Organization: California Univ., San Francisco, CA (United States). Dept. of Pharmaceutical Chemistry
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: FG03-89ER60873
• OSTI ID: 5391334
• Report Number(s): DOE/ER/60873-T1; ON: DE91017406
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400201 -- Chemical & Physicochemical Properties
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALANINES
AMINO ACIDS
BORON COMPOUNDS
CARBOXYLIC ACIDS
CHEMICAL PREPARATION
CHEMICAL REACTION YIELD
CHEMICAL REACTIONS
DEHYDROGENATION
DISEASES
DOCUMENT TYPES
ENANTIOMORPHS
MEDICINE
MELANOMAS
METASTASES
NEOPLASMS
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
PROGRESS REPORT
RADIOLOGY
RADIOTHERAPY
REACTION INTERMEDIATES
SYNTHESIS
THERAPY
YIELDS