131I therapy in differentiated thyroid carcinoma: M. D. Anderson Hospital experience
The therapeutic response and survival rates of 352 patients with differentiated thyroid carcinoma who had received radioactive iodine therapy since 1951 were studied. Of these patients, 72% had metastases to the cervical lymph nodes, lungs, bone, or other viscera. Of all patients, 70% showed complete remission, and 30% showed partial response or recurrence of disease or both. Patients with metastases before therapy had a higher incidence of recurrence than those who had localized thyroid disease (32.4% vs. 15.1%). Of these, 97 patients had recurrent disease. In 24 of these patients, the recurrent tumor failed to take iodine, indicating change in its iodine-concentrating characteristics. Of the 352 patients, 44 (12.5%) died of progressive thyroid carcinoma, and all were over 40 years of age at the time of initial diagnosis. Mean survival of patients with metastatic disease who were over 40 years of age at initial diagnosis was significantly lower than that of patients under 40 years of age (6.2 years vs. 11.5 years). Patients with recurrent metastases unresponsive to surgery or radioactive iodine therapy were treated with palliative radiotherapy or chemotherapy or both. They respond poorly and died within a few months.
- OSTI ID:
- 5390571
- Journal Information:
- Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 47:4; ISSN CANCA
- Country of Publication:
- United States
- Language:
- English
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560171 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
CHEMOTHERAPY
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DEATH
DIAGNOSIS
DISEASES
ENDOCRINE GLANDS
GLANDS
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
LUNGS
LYMPH NODES
LYMPHATIC SYSTEM
MATHEMATICS
MEDICINE
METASTASES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SKELETON
STATISTICS
SURGERY
THERAPY
THYROID