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Clonogenic capacity of cells of mouse NKLy/LL solid tumors and change therein after exposure to radiation

Journal Article · · Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:5388574
; ;
Significant fluctuations were demonstrated in share of clonogenic cells in NKLy/LL tumors in different animals. The curve of survival of clonogenic cells as a function of dosage of ..gamma.. radiation delivered to tumors cultured immediately after exposure is biphasic, and it is characterized by the following parameters: n = 1.34, D/sub q/ = 135.7, D/sub 0/ = 464.4 rad; with delivery of doses in excess of 1.2 krad, D/sub 0/ = 809.8 rad, which is indicative of the presence in tumors of two populations of cells differing in radiosensitivity. When cells are inoculated 24 h after irradiation, the dose-effect curve consists of one branch with the following parameters: n = 1.28, D/sub q/ = 178.3 rad and D/sub 0/ = 740.0 rad. Evidently, the clonogenic cells of NKLy/LL tumors are capable of recovering from potentially lethal lesions, and the degree of recovery increases with the dose of radiation.
Research Organization:
Inst. of Chemical Physics, Moscow, USSR
OSTI ID:
5388574
Journal Information:
Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 18:5; ISSN RADBA
Country of Publication:
United States
Language:
English

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Related Subjects

560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
CLONING
COBALT 60
COBALT ISOTOPES
COLONY FORMATION
CULTIVATION TECHNIQUES
DATA
DATA FORMS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
GAMMA RADIATION
IN VITRO
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY
RECOVERY
RODENTS
SURVIVAL TIME
TUMOR CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES