Statistical analysis of Japanese Thorotrast-administered autopsy cases

Journal Article · Thu Feb 01 00:00:00 EST 1979 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(79)90157-9· OSTI ID:5388387

Mori, T ^[1]; Kato, Y; Shimamine, T; Watanabe, S

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1. Kanagawa Prefectural Coll. of Nursing and Medical Tech., Nakoa, Japan

The causes of death of 144 Japanese autopsy cases during 1945-1975, who had been intravascularly injected with Thorotrast in life, were compared with those of non-Thorotrast-administered autopsy cases in the same age bracket, recorded in the Annals of Japanese Pathological Autopsy Cases during 1958-1973. This comparison revealed that the incidence of malignant hepatic tumors was more than 10 times higher in the Thorotrast-administered cases. The increase was attributable to an increased incidence of hemangioendothelioma and cholangiocarcinoma of the liver. The only significant increase of liver cirrhosis found to exist in the Thorotrast group occurred in the female cases. Some of the Thorotrast-administered cases were found to have developed myeloid leukemia and erythroleukemia. There was also a significant increase in the number of cases of aplastic anemia in the Thorotrast group, but clinically and pathologically these were atypical. Lymphatic leukemia was not observed. No significant difference was found in the incidence of either malignant lymphomas or osteosarcomas in the Thorotrast group and the controls. Lung cancer, on the other hand, showed a significantly higher incidence among the controls than among the Thorotrast-administered cases.

• OSTI ID: 5388387
• Journal Information: Environ. Res.; (United States), Vol. 18:1
• Country of Publication: United States
• Language: English

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