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Correlation of effects of inhaled versus intratracheally injected males on susceptibility to respiratory infection in mice

Journal Article · · Am. Rev. Respir. Dis.; (United States)
OSTI ID:5387186
; ; ; ; ;
Effects of intratracheally administered air pollutant chemicals on susceptibility of mice to infection by aerosolized bacteria were compared with effects of the same chemical previously studied by the inhalation route. Out of 22 compounds previously studied by inhalation, the same 3 (CdSO4, CuSO4, and ZnSO4) that caused significantly increased mortality because of infection after a 3-h exposure to 1 to 2 mg/m3 showed large (greater than or equal to 40% over sham injected) mortality increases when administered by intratracheal injection at lung concentrations calculated to be equivalent to those achieved during inhalation exposures (0.6 to 1.2 microgram). Dose-effect curves of these compounds were similar by the 2 routes. Five of the compounds caused a moderate (20 to 30%) enhancement in the mean excess mortality at concentrations of 2 to 3 microgram/animal. The remaining compounds, which showed no significant effect by inhalation, also showed no effect when given by intratracheal injection. Thus, similar effects on susceptibility to lung bacterial infection were seen whether chemicals were deposited in te lung by inhalation or by intratracheal injection.
OSTI ID:
5387186
Journal Information:
Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 124:2; ISSN ARRDA
Country of Publication:
United States
Language:
English

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Related Subjects

550700 -- Microbiology
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BACTERIA
BIOLOGICAL EFFECTS
CALCULATION METHODS
CHEMICAL EFFLUENTS
COLLOIDS
COMPARATIVE EVALUATIONS
DISPERSIONS
INFECTIVITY
INHALATION
INTAKE
MAMMALS
MICE
MICROORGANISMS
MORTALITY
QUANTITY RATIO
RESPIRATION
RESPIRATORY SYSTEM
RODENTS
SOLS
TRACHEA
VERTEBRATES