Improved radioimmunoassay for thymosin. cap alpha. 1 recognizes the N-14 amino terminus
Conference
·
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:5385632
Thymosin ..cap alpha../sub 1/(T..cap alpha../sub 1/) is a biologically active thymic peptide currently undergoing trials as an immunomodulator in cancer patients and patients with immunodeficiencies. Abnormally elevated levels of T..cap alpha../sub 1/ have been found in the serum of individuals with or at risk for AIDS, with T-cell leukemias, and chronic progressive multiple sclerosis. Absorption of the current antibody with a synthetic C-14 fragment of T..cap alpha../sub 1/ results in an antisera specific for the N-14 amino terminus of T..cap alpha../sub 1/, which measures significantly higher levels of T..cap alpha../sub 1/ in serum from normal individuals and significantly increases the sensitivity of the assay. Ongoing studies indicate that this new RIA for T..cap alpha../sub 1/ will be useful in monitoring changes of immunoreactive T..cap alpha../sub 1/ in serum with age and in patients with known or suspected T-cell abnormalities.
- Research Organization:
- George Washington Medical Center, Washington, DC
- OSTI ID:
- 5385632
- Report Number(s):
- CONF-8604222-
- Conference Information:
- Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AGING
AIDS
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
HEMIC DISEASES
HORMONES
IMMUNE REACTIONS
IMMUNOASSAY
IMMUNOLOGY
INFECTIOUS DISEASES
ISOTOPE APPLICATIONS
LEUKEMIA
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MATERIALS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PEPTIDES
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
SOMATIC CELLS
THYMUS
TRACER TECHNIQUES
VIRAL DISEASES
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AGING
AIDS
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
HEMIC DISEASES
HORMONES
IMMUNE REACTIONS
IMMUNOASSAY
IMMUNOLOGY
INFECTIOUS DISEASES
ISOTOPE APPLICATIONS
LEUKEMIA
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MATERIALS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PEPTIDES
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
SOMATIC CELLS
THYMUS
TRACER TECHNIQUES
VIRAL DISEASES