Toxic effects of acrylamide in a freshwater fish, Heteropneustes fossilis
It has been shown that acrylamide is a cumulative neurotoxic agent and can conjugate with glutathione enzymically and nonenzymically. The enzymic conjugation is catalyzed by a cytosolic enzyme, glutathione S-transferase. Laboratory animals exposed to acrylamide exhibited a decrease in glutathione level and in the activity of glutathione-S-transferase of brain and liver. The inhibition of glutathione-S-transferase by acrylamide, which catalyzes its conjugation with glutathione, may lead to the accumulation of the monomer and its enhanced neurotoxicity. At present little is known about the toxic effects of acrylamide in fishes. The present study deals with the determination of median lethal concentration (LC50) of acrylamide and its effect on the hepatic glutathione and glutathione-S-transferase levels of the fresh water fish, Heteropneustes fossilis.
- Research Organization:
- Industrial Toxicology Research Centre, Lucknow, India
- OSTI ID:
- 5384917
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 37:2; ISSN BECTA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRYLAMIDE
AMIDES
AMINOTRANSFERASES
ANIMALS
AQUATIC ORGANISMS
BIOLOGICAL EFFECTS
DRUGS
ENZYME ACTIVITY
ENZYMES
FISHES
GLUTATHIONE
NITROGEN TRANSFERASES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PEPTIDES
POLLUTION
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
TRANSFERASES
VERTEBRATES
WATER POLLUTION