(Non-invasive evaluation of the cardiac autonomic nervous system by PET)
Our research efforts in the first funding year concentrated on animal and clinical studies validating {sup 11}C-hydroxyephedrine as a marker for norepinephrine uptake and storage in presynaptic sympathetic nerve terminals. In addition to kinetic studies in animals, the first clinical studies have been performed. {sup 11}C-hydroxyephedrine provides excellent image quality in the human heart with high myocardium to blood ratios. A canine model with transient intracoronary occlusion of the left anterior descending aorta was used to show decreased retention of tracer with ischemia. Clinical studies of patients with acute myocardial infarction showed an area of decreased retention of tracer exceeding the infarct territory as defined by {sup 82}Rb blood flow imaging. We are also developing tracers for the parasympathetic nervous system. It appears that methyl-TRB is a specific tracer for this system. Studies of {sup 11}C- or {sup 18}F-benzovesamicol as a potential tracer for parasympathetic presynaptic nerve terminals are under way. (MHB)
- Research Organization:
- Michigan Univ., Ann Arbor, MI (United States). Div. of Nuclear Medicine
- Sponsoring Organization:
- DOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG02-90ER61091
- OSTI ID:
- 5381369
- Report Number(s):
- DOE/ER/61091-1; ON: DE91018476
- Country of Publication:
- United States
- Language:
- English
Similar Records
[Non-invasive evaluation of the cardiac autonomic nervous system by PET]. Progress report
Noninvasive evaluation of the cardiac autonomic nervous system. Final progress report, December 24, 1993--February 28, 1994
Related Subjects
551000 -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METAL ISOTOPES
ALKALOIDS
AMINES
AUTONOMIC NERVOUS SYSTEM
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MODELS
BLOOD FLOW
BODY
CARBON 11
CARBON ISOTOPES
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EPHEDRINE
EVEN-ODD NUCLEI
FLUORINE 18
FLUORINE ISOTOPES
HEART
HISTOLOGY
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
MEMBRANE PROTEINS
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NANOSEC LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
POSITRON COMPUTED TOMOGRAPHY
PROGRESS REPORT
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RECEPTORS
RUBIDIUM 82
RUBIDIUM ISOTOPES
SCINTISCANNING
SYMPATHOMIMETICS
TISSUE DISTRIBUTION
TOMOGRAPHY
TRACER TECHNIQUES
VASOCONSTRICTORS