Gas chromatographic/mass spectrometric determination of aniline in foods oils associated with the Spanish toxic oil syndrome

Journal Article · Tue Sep 01 04:00:00 UTC 1987 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01688318· OSTI ID:5379289

Hill, Jr, R H; Todd, G D; Kilbourne, E M; Cline, R E; McCraw, J; Orti, D L; Bailey, S L; Needham, L L

In 1981, a new disease, known today as the toxic oil syndrome (TOS), descended upon the people of Spin. A strong association between TOS and contaminated food oil was established early. Subsequent investigations implicated food oils containing rapeseed oil denatured with aniline. However, little aniline was found in the oils; some other etiologic agent in the oil had apparently produced the illness. Many researchers have investigated these oils, but the specific etiologic agent has not been identified. Significant progress in this research has been hampered by the difficulty in identifying the specific oil samples that produced illness in specific TOS cases. In 1984, the Spanish Government invited the Centers for Disease Control (CDC) to participate in its research efforts to study the TOS problem. One of the authors was detailed to Spain to assist in the study of the illness. Part of their work in this area has been an attempt in their laboratories to classify a group of blind-coded case and control oils according to selected chemical measurements. They report here a newly developed method for determining aniline in these oils and the results of these analyses.

• Research Organization: Dept. of Health and Human Services, Atlanta, GA (USA)
• OSTI ID: 5379289
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 39:3; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560300* -- Chemicals Metabolism & Toxicology
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANILINE
AROMATICS
CARBON 12
CARBON 13
CARBON ISOTOPES
CHEMICAL ANALYSIS
CHROMATOGRAPHY
DEVELOPING COUNTRIES
ESTERS
EUROPE
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
FOOD
GAS CHROMATOGRAPHY
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
LIPIDS
MASS SPECTROSCOPY
NUCLEI
OILS
OLIVE OIL
ORGANIC COMPOUNDS
OTHER ORGANIC COMPOUNDS
SEPARATION PROCESSES
SPAIN
SPECTROSCOPY
STABLE ISOTOPES
TRACER TECHNIQUES
TRIGLYCERIDES
VEGETABLE OILS
WESTERN EUROPE