Cadmium-induced anemia in growing pigs: protective effect of oral or parenteral iron

Journal Article · Mon Jan 01 00:00:00 EST 1973 · J. Anim. Sci.; (United States)

OSTI ID:5376819

Pond, W G; Walker, Jr, E F; Kirtland, D

Forty-two weanling Yorkshire pigs were used in two experiments to determine the effect of oral or injected Fe on the anemia and growth depression induced by dietary Cd. In both experiments 154 ppm Cd (as CdCl/sub 2/) added to a corn-soybean meal diet significantly (P < .01) depressed hemoglobin; in experiment 2, daily weight gain and feed consumption were significantly (P < .01) depressed by Cd. The depression in hemoglobin induced by Cd was prevented by oral (400 ppm Fe as FeSO/sub 4/ 7H/sub 2/O) or intramuscular (800 mg Fe as iron dextrin) Fe (experiment 1) or by intramuscular (1000 mg Fe as iron dextrin) Fe (experiment 2). Daily weight gain of pigs fed the basal diet was not significantly different from that of pigs fed Cd when Fe was injected (experiment 2). Oral Fe was incorporated into the feed throughout the experiment; parenteral Fe was administered as a single intramuscular injection on day 1 of each experiment. The protective effect of Fe on Cd-induced anemia observed previously in the rat is apparently operative in the pig as well.

• Research Organization: Cornell Univ., Ithaca, NY
• OSTI ID: 5376819
• Journal Information: J. Anim. Sci.; (United States), Vol. 36:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
BIOLOGICAL EFFECTS
ANEMIAS
BLOOD
EXPERIMENTAL DATA
IRON
RESPONSE MODIFYING FACTORS
SWINE
THERAPY
ANIMALS
BIOLOGICAL MATERIALS
BODY FLUIDS
DATA
DISEASES
DOMESTIC ANIMALS
ELEMENTS
HEMIC DISEASES
INFORMATION
MAMMALS
MATERIALS
METALS
NUMERICAL DATA
SYMPTOMS
TRANSITION ELEMENTS
VERTEBRATES
560305* - Chemicals Metabolism &amp; Toxicology- Vertebrates- (-1987)