Experimentally induced lead poisoning in goats: clinical observations and pathologic changes

Journal Article · Fri Oct 01 00:00:00 EDT 1976 · Cornell Vet.; (United States)

OSTI ID:5375694

Davis, J W; Libke, K G; Watson, D F; Bibb, T L

The effects of orally administered lead acetate were investigated in 9 adult and 3 kid goats by clinical and necropsy studies. One kid and 6 adults died after having received from 100 to 1392.5 Gm each, given over periods of from 10 to 52 days. Anorexia, diarrhea and body weight loss occurred in all lead treated goats in the study. Basophilic stippling of red blood cells was found in 6 of 8 animals on which weekly hemograms were performed. The pathological changes were essentially the same as those that have been recorded for other ruminant species with lead poisoning. Intranuclear acid-fast inclusions in the cells of the proximal convoluted tubules of the kidney were demonstrated in 9 of 12 lead treated goats and in the liver parenchymal cells of 2 of these animals.

• Research Organization: Virginia Polytechnic Institute and State Univ., Blacksburg
• OSTI ID: 5375694
• Journal Information: Cornell Vet.; (United States), Vol. 66:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LEAD
TOXICITY
BLOOD
BRAIN
DIGESTIVE SYSTEM
EXPERIMENTAL DATA
GOATS
HISTOLOGICAL TECHNIQUES
KIDNEYS
SPLEEN
URINARY TRACT
WEIGHT MEASUREMENT
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CENTRAL NERVOUS SYSTEM
DATA
DOMESTIC ANIMALS
ELEMENTS
INFORMATION
MAMMALS
MATERIALS
METALS
NERVOUS SYSTEM
NUMERICAL DATA
ORGANS
RUMINANTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)