Effects of estrogens and progestins on high density lipoproteins
High density lipoprotein (HDL) levels are knwon to be higher in women than in men, and to increase with estrogen use. To assess the effects of estrogens on HDL subspecies, analytic ultracentrifuge measurements of HDL were compared in 11 menopausal estrogen users and 16 controls. The difference in mean schlieren patterns between the groups showed a significantly higher level of HDL with flotation rate (F/sub 1/ /sub 20//sup 0/) > 1.5 (predominantly HDL/sub 2/) in the users. This was similar to the difference in HDL seen between nonusers of hormones and age-matched males. A previous study had shown that users of combination oral contraceptives had increased levels of HDL with F/sub 1/ /sub 20//sup 0/ less than or equal to 3.5 (primarily HDL/sub 3/) suggesting that the estrogen effect on HDL is altered by the presence of added progestin. The progestin effect was studied here in detail in two women with type V hyperlipoproteinemia treated with norethindrone acetate. Reduction in serum triglyceride was accompanied by a reduction in HDL, predominantly in the less dense species (HDL/sub 2/). Among groups of oral contraceptive and noncontraceptive estrogen and progestin users whose HDL-cholesterol levels have been reported recently, there was a direct correlation (r = 0.86, p < .001) between mean HDL-cholesterol and triglyceride levels. Endogenous hormonal influences on HDL were assessed by serum hormone and lipoprotein measurements at weekly intervals during two consecutive menstrual cycles in four healthy females. An increase in HDL of highest flotation rate (F/sub 1/ /sub 20//sup 0/ 5 to 9) was seen, which corresponded with the time of ovulation, raising the possibility of pituitary as well as gonadal hormone effects on HDL.
- Research Organization:
- Univ. of California, Berkeley
- OSTI ID:
- 5372342
- Journal Information:
- Lipids; (United States), Vol. 14:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ESTROGENS
BIOLOGICAL EFFECTS
LIPOPROTEINS
METABOLISM
PROGESTERONE
COMPARATIVE EVALUATIONS
DENSITY
ESTROUS CYCLE
FEMALES
MALES
PATIENTS
QUANTITY RATIO
RESPONSE MODIFYING FACTORS
SEX DEPENDENCE
ULTRACENTRIFUGES
CENTRIFUGES
CONCENTRATORS
HORMONES
KETONES
LIPIDS
ORGANIC COMPOUNDS
PHYSICAL PROPERTIES
PREGNANES
PROTEINS
STEROID HORMONES
STEROIDS
550500* - Metabolism
550600 - Medicine