Acute effects of cadmium on the spot Leiostomus xanthurus (teleostei): tissue distribution and renal ultrastructure

Journal Article · Sat Mar 01 04:00:00 EST 1980 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398009529852· OSTI ID:5366044

Hawkins, W E; Tate, L G; Sarphie, T G

Spot (Leiostomus xanthurus) was exposed to 1, 5, 10, 15, and 25 ppM cadmium chloride for 48 h. Analysis by atomic absorption spectrophotometry showed that cadmium accumulated mainly in the liver, followed by heart, gut, kidney, and gill. Brain and body muscle did not concentrate the metal. Electron microscopy showed that the proximal tubule cells were severely affected by cadmium levels of 10, 15, and 25 ppM. The proximal tubule cells exhibited responses that ranged from an increase in heterogeneous bodies to epithelial desquamation. Mitochondria of degenerating proximal tubule cells showed changes similar to metal-poisoned mammalian kidney cells. Some mitochondria were contracted and dense while others were swollen with granular matrices and focal electron densities. In exposures of 25 ppM, Bowman's space of the renal corpuscle was swollen and often contained cellular debris. This study showed that after acute exposure to cadmium the metal accumulated mainly in visceral organs of the spot and at levels of 10 ppM and greater resulted in severe damage to proximal tubule cells of the kidney.

• Research Organization: Univ. of South Alabama, Mobile
• OSTI ID: 5366044
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 6:2; ISSN JTEHD
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ANIMAL CELLS
ANIMALS
AQUATIC ORGANISMS
BIOLOGICAL EFFECTS
BODY
CADMIUM
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
DIGESTIVE SYSTEM
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
FISHES
GASTROINTESTINAL TRACT
GILLS
GLANDS
HEART
INJURIES
KIDNEYS
LIVER
METALS
MITOCHONDRIA
MORPHOLOGICAL CHANGES
ORGANOIDS
ORGANS
RESPIRATORY SYSTEM
TISSUE DISTRIBUTION
TOXICITY
TUBULES
ULTRASTRUCTURAL CHANGES
VERTEBRATES