S-phase fractions of colorectal carcinomas related to pathologic and clinical features
Journal Article
·
· Cancer (Philadelphia); (United States)
DOI:https://doi.org/10.1002/1097-0142(19810901)48:5<1221::AID-CNCR2820480528>3.0.CO;2-B·
OSTI ID:5365944
The S-phase fractions (SPFs) of epithelial cells in 100 resected colorectal carcinomas were measured by in vitro exposure to tritiated thymidine and autoradiography. The frequency distribution of SPFs was gaussian with a median of 17.8 per hundred in 90 unirradiated carcinomas, whereas in ten carcinomas given radiation therapy preoperatively, it was positively skewed with a median of 6.9. Analysis of the unirradiated carcinomas showed no relationship between SPF and various clinical and morphologic features that included age, race, sex, site, size, Dukes' stage, histologic grade of the tumor, number of metastasis-bearing regional lymph nodes, presence of adenomas of the large bowel, survival or relapse-free survival of the patient, or SPF or adjacent normal colorectal crypts. The results show no evidence that colorectal carcinomas can be divided into kinetic subsets. The spatial orientation of labeled cells in autoradiographs indicated presence of a nonproliferative fraction of cells in many tumors that may modulate response to radiation therapy and chemotherapy.
- OSTI ID:
- 5365944
- Journal Information:
- Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 48:5; ISSN CANCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550301 -- Cytology-- Tracer Techniques
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMAL TISSUES
AUTORADIOGRAPHY
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
CELL CYCLE
CELL PROLIFERATION
DIGESTIVE SYSTEM
DISEASES
EPITHELIUM
EXTERNAL IRRADIATION
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
INTESTINES
IRRADIATION
LABELLED COMPOUNDS
LARGE INTESTINE
MEDICINE
MORPHOLOGY
NEOPLASMS
NUCLEAR MEDICINE
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGY
PYRIMIDINES
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
RECTUM
RIBOSIDES
THERAPY
THYMIDINE
TISSUES
TRITIUM COMPOUNDS
TUMOR CELLS
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMAL TISSUES
AUTORADIOGRAPHY
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
CELL CYCLE
CELL PROLIFERATION
DIGESTIVE SYSTEM
DISEASES
EPITHELIUM
EXTERNAL IRRADIATION
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
INTESTINES
IRRADIATION
LABELLED COMPOUNDS
LARGE INTESTINE
MEDICINE
MORPHOLOGY
NEOPLASMS
NUCLEAR MEDICINE
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGY
PYRIMIDINES
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
RECTUM
RIBOSIDES
THERAPY
THYMIDINE
TISSUES
TRITIUM COMPOUNDS
TUMOR CELLS