Metabolism of selenium in skeletal muscle and liver of mice with genetic muscular dystrophy

Journal Article · Thu Feb 01 04:00:00 EST 1979 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-160-40406· OSTI ID:5365817

Revis, N W; Horton, C Y; Curtis, S

The specific activity of glutathione peroxidase and the concentration of selenium in muscles from mice with genetic muscular dystrophy were both significantly increased over those of control mice. Following pretreatment with sodium selenite (10 ..mu..g/100 g body wt) for 3 days, the specific activity of glutathione peroxidase and the concentration of selenium in muscle from the dystrophic mice were both significantly increased over values in muscle from control mice. When the dystrophic and control mice were fed a diet deficient in selenium, both the activity of glutathione peroxidase and the selenium concentration were significantly decreased in muscle from both groups. However, the magnitude of decrease was significantly greater in the muscle from the control mice than in the muscle from the dystrophic mice. These results suggest that muscle from dystrophic mice has a greater capacity for selenium absorption and retention than does muscle from control mice.

• Research Organization: Oak Ridge National Lab., TN
• OSTI ID: 5365817
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 160:2; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

551001 -- Physiological Systems-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
CARBOXYLIC ACIDS
CATALYSIS
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ENZYME ACTIVITY
ENZYMES
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
GLUTATHIONE
HEREDITARY DISEASES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOLATED VALUES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MAMMALS
METABOLISM
MICE
MUSCLES
NUCLEI
NUMERICAL DATA
NUTRITIONAL DEFICIENCY
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
PEPTIDES
PEROXIDASES
POLYPEPTIDES
PORPHYRINS
PROTEINS
RADIOISOTOPES
REACTION KINETICS
RESPONSE MODIFYING FACTORS
RETENTION
RODENTS
SELENIUM
SELENIUM 75
SELENIUM ISOTOPES
SEMIMETALS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES