Long-term effects of radium exposure in female dial workers: liver function and liver disease
The question of the long-term effects of ..cap alpha..-emitting radionuclides on the liver is of considerable interest. Liver function test results and data on the prevalence of and mortality from diseases of the liver and biliary tract were examined among women who were first employed before 1930 in the US radium watch-dial painting industry, and who had a radium body-burden measurement while living (1958 to 1976). There was little evidence for a relationship between radium intake dose (initial systemic burden in ..mu..Ci) and serum levels of albumin, total bilirubin, glutamic oxaloacetic transaminase (SGOT), or cholesterol in 142 long-term survivors, using both univariate and multivariate satistical analyses. Mean SGOT level was significantly higher in the highest intake dose (greater than or equal to 50 ..mu..Ci) than in the lower intake-dose groups, suggesting the need for continued clinical follow-up. Among 264 women with a serum alkaline phosphatase determination, a lack of significant association with intake-dose was noted. The prevalence of diagnosed diseases of the liver or biliary tract (i.e., cirrhosis, infectious hepatitis, and cholecystitis) was not significantly related to intake-dose level in 683 women, nor were the observed numbers of deaths from cirrhosis of the liver or liver cancer significantly increased relative to the US white female population. The findings were discussed in terms of estimated absorbed (rad)doses and in relation to the findings of studies on other radiation-exposed human populations.
- Research Organization:
- Argonne National Lab., IL
- OSTI ID:
- 5365073
- Journal Information:
- Environ. Res.; (United States), Vol. 18:2
- Country of Publication:
- United States
- Language:
- English
Similar Records
Safety and Efficacy of Percutaneous Biliary Covered Stent Placement in Patients with Malignant Biliary Hilar Obstruction; Correlation with Liver Function
Radiation and Risk of Liver, Biliary Tract, and Pancreatic Cancers among Atomic Bomb Survivors in Hiroshima and Nagasaki: 1958–2009
Related Subjects
BILIARY TRACT
DELAYED RADIATION EFFECTS
BLOOD SERUM
DIAL PAINTERS
PERSONNEL MONITORING
FEMALES
LIVER
RADIUM
ALBUMINS
AMINOTRANSFERASES
BILIRUBIN
CHOLESTEROL
DOSE-RESPONSE RELATIONSHIPS
INDUSTRIAL MEDICINE
QUANTITATIVE CHEMICAL ANALYSIS
TOXICITY
ALKALINE EARTH METALS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOXYLIC ACIDS
CHEMICAL ANALYSIS
DIGESTIVE SYSTEM
ELEMENTS
ENZYMES
GLANDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
MEDICINE
METALS
MONITORING
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PERSONNEL
PIGMENTS
PROTEINS
PYRROLES
RADIATION EFFECTS
RADIATION MONITORING
STEROIDS
STEROLS
TRANSFERASES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
560115 - Radiation Effects on Biochemicals- In Man- (-1987)
560200 - Thermal Effects