Receptors for sensory neuropeptides in human inflammatory diseases: Implications for the effector role of sensory neurons

Journal Article · Mon May 01 04:00:00 EDT 1989 · Peptides (Fayetteville, New York); (USA)

DOI:https://doi.org/10.1016/0196-9781(89)90154-X· OSTI ID:5363694

Mantyh, P W; Catton, M D; Boehmer, C G; Welton, M L; Passaro, Jr, E P; Maggio, J E; Vigna, S R ^[1]

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1. VA Medical Center-Wadsworth, Los Angeles, CA (USA)

Glutamate and several neuropeptides are synthesized and released by subpopulations of primary afferent neurons. These sensory neurons play a role in regulating the inflammatory and immune responses in peripheral tissues. Using quantitative receptor autoradiography we have explored what changes occur in the location and concentration of receptor binding sites for sensory neurotransmitters in the colon in two human inflammatory diseases, ulcerative colitis and Crohn's disease. The sensory neurotransmitter receptors examined included bombesin, calcitonin gene related peptide-alpha, cholecystokinin, galanin, glutamate, somatostatin, neurokinin A (substance K), substance P, and vasoactive intestinal polypeptide. Of the nine receptor binding sites examined only substance P binding sites associated with arterioles, venules and lymph nodules were dramatically up-regulated in the inflamed tissue. These data suggest that substance P is involved in regulating the inflammatory and immune responses in human inflammatory diseases and indicate a specificity of efferent action for each sensory neurotransmitter in peripheral tissues.

• OSTI ID: 5363694
• Journal Information: Peptides (Fayetteville, New York); (USA), Journal Name: Peptides (Fayetteville, New York); (USA) Vol. 10:3; ISSN PPTDD; ISSN 0196-9781
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
AUTORADIOGRAPHY
BIOLOGICAL FUNCTIONS
DIGESTIVE SYSTEM DISEASES
DISEASES
FUNCTIONS
IMMUNE REACTIONS
INFLAMMATION
IODINE ISOTOPES
ISOTOPES
MAMMALS
MAN
MEMBRANE PROTEINS
NERVE CELLS
ORGANIC COMPOUNDS
PATHOGENESIS
PATHOLOGICAL CHANGES
PEPTIDES
PRIMATES
PROTEINS
RECEPTORS
SOMATIC CELLS
SYMPTOMS
VERTEBRATES